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Tetanus — History of Vaccines


This micrograph depicts a group of Clostridium tetani bacteria, responsible for causing tetanus in humans.
This neonate is displaying a bodily rigidity produced by Clostridium tetani exotoxin, called “neonatal tetanus”. Neonatal tetanus occurs in infants born without protective passive immunity, because the mother is not immune.

Symptoms and Causative Agent

Tetanus is a disease of the nervous system caused by bacteria called Clostridium tetani. This bacterium produces two exotoxins, one of which (tetanospasmin) is a neurotoxin that causes the symptoms of tetanus.

The early symptoms of the disease are lockjaw (the most recognizable of its physical effects), stiffness, and problems swallowing. Later symptoms include severe muscle spasms, seizure-like activity, and severe nervous system disorders. Generally, between 10% and 20% of tetanus cases result in death, though fatalities are more likely among patients older than 60 years of age, and among unimmunized individuals. In the most common type of reported tetanus (“generalized tetanus”), spasms continue for 3-4 weeks, and recovery may take months.

Neonatal tetanus refers to a case of tetanus in a newborn infant whose mother was not immune to the disease. It is rare in the United States, but common in certain developing countries.


Tetanus is not passed from person to person; it is unusual among vaccine-preventable diseases in this regard. Instead, tetanus is transmitted via the entry of Clostridium tetani bacteria into injured skin and underlying tissues. Surprisingly, tetanus infection is more likely from a minor wound than a major one, but this is because severe wounds are more likely to be properly treated and cleaned. The incubation period is between three and 21 days.

C. tetani is widespread in spore form in soil, as well as in the intestines and feces of animals (including cats, dogs, rats, guinea pigs, chickens, horses, sheep, and cattle). It also found on skin and has been found in contaminated heroin. Although C. tetani is heat-sensitive and cannot survive in the presence of oxygen in early stages of growth, C. tetani spores, which develop as the bacteria mature, are extremely hardy. They can survive temperatures of nearly 250°F for 10-15 minutes, and are resistant to antiseptics.

Treatment and Care

For patients suffering from spasms, supportive treatment is provided, and procedures are performed to maintain an open airway. Treatment of the underlying illness generally involves tetanus immune globulin (TIG) to remove tetanus toxin that has not yet bound to nerve endings.

It should be noted that surviving a tetanus infection does not result in future immunity to the disease. Tetanus immunization is recommended for survivors after full recovery.

Complications and Mortality

Complications from tetanus can be quite severe. Spasms of the vocal cords or the muscles used for respiration can cause breathing problems; sustained muscle spasms and convulsions can result in broken bones. The disease’s effects on the nervous system can lead to high blood pressure and abnormal heart rhythms.

Available Vaccines and Vaccination Campaigns

Protection against tetanus is provided via tetanus toxoid—inactivated tetanus toxin, which is available both as a single immunization against tetanus alone, and in multiple combination preparations (the two most common are DTaP, which provides protection against diphtheria, tetanus, and pertussis for children younger than seven; and Td, which protects against tetanus and diphtheria for people seven or older).

The extreme rarity of tetanus cases among individuals immunized up to 10 years prior to infection suggests an efficacy rate of nearly 100% for tetanus toxoid. Immunity levels do decrease with time, however, so that boosters against tetanus are recommended every 10 years in order to maintain protection against the disease.

A tetanus booster is recommended for individuals who sustain any wound that is not clean and minor, if more than five years have passed since their last dose of tetanus toxoid.

U.S. Vaccination Recommendations

The U.S. childhood immunization schedule recommends five doses of DTaP to provide protection against tetanus, as well as diphtheria and pertussis, with the first dose given at two months of age.

The Td (tetanus and diphtheria) immunization is given to both adolescents and adults every 10 years as a booster (or, in some cases, after a tetanus exposure). It is recommended that one dose of Td be replaced with Tdap (tetanus, diphtheria, and pertussis) for adults 19 and older to boost immunity against whooping cough.


Centers for Disease Control and Prevention. Epidemiology and Prevention of Vaccine-Preventable Diseases. Tetanus. Atkinson W, Wolfe S, Hamborsky J, McIntyre L, eds. 13th ed. Washington DC: Public Health Foundation, 2009. Accessed 2/23/2016.


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Last update 23 Feb 2016

Timeline Entry: 1948 Whooping Cough: Vaccine Combined with Those for Tetanus and Diphtheria

Combined diphtheria, whooping cough, and tetanus vaccination

The first combined DTP (diphtheria, tetanus, and pertussis) vaccines became available in the United States. This type of combined shot used a whole-cell pertussis vaccine; decades later, in the mid-1990s, the whole-cell vaccine would be replaced with an acellular version that resulted in fewer adverse reactions.

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Timeline Entry: 1999 Whooping Cough: Acellular Vaccine Recommended

A combined dipthertia, tetanus and pertussis (whooping cough) vaccine, DTaP, that used an acellular pertussis vaccine, replaced the DTP vaccination on the U.S. Recommended Childhood Immunization Schedule. The acellular vaccine used only parts of the pertussis pathogen in order to generate immunity, and resulted in fewer side effects than the whole-cell vaccine that had been used in DTP. Eventually, the United States would cease the use of DTP completely in favor of DTaP.

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Assessment Questions

Tetanus is a disease of the __________ system.
A) digestive
B) respiratory
C) nervous
D) skeletal
True or false? Tetanus is passed from person to person.
A) True
B) False
In order to maintain protection against tetanus, booster vaccinations are recommended every __________ years.
A) 2
B) 5
C) 8
D) 10
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