Which vaccine pioneer developed more than 40 vaccines?
Edward Jenner
Louis Pasteur
Jonas Salk
Maurice Hilleman
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Microbiologist Maurice Hilleman developed many vaccines used today. Read more

 

Pertussis ( Whooping Cough )

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Bordetella pertussis bacteria, SEM x5,000
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Symptoms and Causative Agent

Pertussis, also known as whooping cough, is an extremely contagious disease caused by the Bordetella pertussis bacterium. These bacteria produce toxins that paralyze parts of respiratory cells, leading to inflammation in the respiratory tract.

The incubation period for pertussis is generally between 7-10 days long, but can last more than a month. After symptoms first appear, the disease can take anywhere from weeks to months to fully run its course.

Initial symptoms include runny nose, sneezing, and a mild cough, which may seem like a typical cold. A mild fever also generally occurs. However, the cough slowly becomes more severe. Eventually the patient experiences bouts of rapid coughing followed by the “whooping” sound that gives the disease its common name as they try to inhale. While the coughing fit is occurring, the patient may turn blue.

While symptoms may be less severe for adults, pertussis can be extremely dangerous for infants and young children.

In between bouts of coughing, the person typically does not appear to be ill.

Transmission

Although cases of pertussis have dropped dramatically in the United States since the introduction of the pertussis vaccine, the disease has caused widespread outbreaks in recent years. In 2012, nearly 50,000 cases of pertussis were reported in the United States, the most cases since 1955. Twenty pertussis deaths were reported in 2012. Fifteen of those deaths occurred in infants too young to have received the vaccine.

Pertussis also remains a major problem in the developing world. The World Health Organization estimates that pertussis caused 89,000 deaths worldwide in 2012.

The tendency of pertussis to be milder in adults, sometimes escaping diagnosis, further complicates disease transmission. The coughing associated with the disease may be mild enough in an adult case to be written off as a simple cold. The adult, however, will still be contagious and can easily spread the disease to infants too young to be vaccinated, or to individuals whose immunity has waned.

Treatment and Care

Treatment for pertussis is generally limited to supportive care. Antibiotics are sometimes used; however, this is primarily done to remove the Bordetella pertussis bacteria from an infected patient’s secretions, thus reducing her ability to infect others. Antibiotic treatment is unlikely to affect the course of the illness unless administered very early on.

Antibiotics may be given to individuals in contact with the patient in order to prevent infection.

Complications

Infants younger than six months of age are particularly at risk for complications and death from pertussis. Complications include pneumonia (bacterial or viral), seizures, ear infections, and dehydration, among others; in adults, rib fracture from coughing is also possible.

The most common of these complications in infants is B. pertussis pneumonia, which accompanies almost all deaths from pertussis.

Available Vaccines and Vaccination Campaigns

Immunization against pertussis is available for children via the combination DTaP (diphtheria, tetanus, and pertussis) vaccine. The DTaP vaccination replaced the previously used DTP shot, which protected against the same three diseases but used a whole-cell preparation in the pertussis component—that is, it contained inactivated, but complete, Bordetella pertussis bacteria. For the DTaP combination vaccine, the whole-cell preparation was removed; “aP” stands for “acellular pertussis.” This vaccine provides protection against the disease by using only pieces of the pertussis bacteria, which results in fewer side effects than the whole-cell preparation.

A similar combination vaccine called Tdap offers booster protection against tetanus, diphtheria, and pertussis for adolescents and adults in certain situations.

U.S. Vaccination Recommendations

Immunization against pertussis is included on the U.S. childhood immunization schedule as part of the combined DTaP (diphtheria, tetanus, and pertussis) shot. This vaccine is given in several doses, with the first recommended at two months of age, and the last between age four and six years.

A booster dose of pertussis vaccine via the Tdap combined immunization is recommended for adolescents and also for adults over age 19. Pregnant women are recommended to get a booster dose of Tdap during the third trimester of pregnancy. Your doctor can tell you more about when to consider a Tdap booster.


Sources

Centers for Disease Control and Prevention. 2012 Final Pertussis Surveillance. http://www.cdc.gov/pertussis/downloads/pertussis-surveillance-report.pdf (134 KB). Accessed 7/31/2014.

Centers for Disease Control and Prevention. Epidemiology and Prevention of Vaccine-Preventable Diseases. Atkinson W, Wolfe S, Hamborsky J, McIntyre L, eds. 11th ed. Washington DC: Public Health Foundation, 2009. http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/pert.pdf. (730 KB). Accessed 7/31/2014.

Centers for Disease Control and Prevention. Pertussis Cases by Year, 1922-2013. http://www.cdc.gov/pertussis/surv-reporting/cases-by-year.html Accessed 7/31/2014.

Centers for Disease Control and Prevention. Pertussis. Summary of Vaccine Recommendations. http://www.cdc.gov/vaccines/vpd-vac/pertussis/recs-summary.htm Accessed 7/31/2014.

Centers for Disease Control and Prevention Vaccine Information Sheet (VIS), DTaP. http://www.cdc.gov/vaccines/hcp/vis/vis-statements/dtap.html Accessed 7/31/2014.

Paddock CD, Sanden GN, Cherry JD, et. al. Pathology and pathogenesis of fatal Bordetella pertussis infection in infants. Clinical Infect Dis. 2008; 328-38.

Pertussis Vaccination: Use of Acellular Pertussis Vaccines Among Infants and Young Children Recommendations of the Advisory Committee on Immunization Practices (ACIP). (1997) Morbidity and Mortality Weekly Report, 46(RR-7);1-25. http://www.cdc.gov/mmwr/preview/mmwrhtml/00048610.htm. Accessed 7/31/2014.

World Health Organization. Pertussis. Immunization, Vaccines, and Biologicals. http://www.who.int/immunization/monitoring_surveillance/burden/vpd/surveillance_type/passive/pertussis/en/index.html Accessed 7/31/2014.

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Last update 31 July 2014

Timeline Entry: 1906 Whooping Cough: Bacteria Isolated

Centers for Disease Control and Prevention
Bordetella pertussis bacteria
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Belgian scientists Jules Bordet (1870-1961) and Octave Gengou (1875-1957) isolated the bacterium Bordetella pertussis, the causative agent of pertussis (whooping cough), which they had first observed in 1900. It would later also come to be known as the Bordet-Gengou bacillus.

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Timeline Entry: 1948 Whooping Cough: Vaccine Combined with Those for Tetanus and Diphtheria

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Combined diphtheria, whooping cough, and tetanus vaccination
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The first combined DTP (diphtheria, tetanus, and pertussis) vaccines became available in the United States. This type of combined shot used a whole-cell pertussis vaccine; decades later, in the mid-1990s, the whole-cell vaccine would be replaced with an acellular version that resulted in fewer adverse reactions.

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Timeline Entry: 1999 Whooping Cough: Acellular Vaccine Recommended

A combined dipthertia, tetanus and pertussis (whooping cough) vaccine, DTaP, that used an acellular pertussis vaccine, replaced the DTP vaccination on the U.S. Recommended Childhood Immunization Schedule. The acellular vaccine used only parts of the pertussis pathogen in order to generate immunity, and resulted in fewer side effects than the whole-cell vaccine that had been used in DTP. Eventually, the United States would cease the use of DTP completely in favor of DTaP.

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Assessment Questions

Pertussis is caused by __________.
A) bacteria
B) viruses
C) fungi
D) none of the above
True or false? Pertussis symptoms usually go away after a few days.
A) True
B) False
Pertussis is especially dangerous for __________.
A) teenagers
B) adults
C) infants
D) the very old
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