Which vaccine was tested in a landmark U.S. trial in 1954?
Poliovirus vaccine
Measles vaccine
Smallpox vaccine
Meningococcal vaccine
A

The 1954 polio vaccine trial remains the largest ever. Read more

 

History of Polio ( Poliomyelitis )

Copyright Dennis Kunkel Microscopy, Inc.
Transmission electron micrograph of poliovirus, x46,050
 
The Historical Medical Library of The College of Physicians of Philadelphia
Polio patients performing therapeutic exercises, New York, circa 1914
 
CDC/Mr. Stafford Smith
Crowd waiting for 1962 oral polio vaccination
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Few diseases frightened parents more in the early part of the 20th century than did polio. Polio struck in the warm summer months, sweeping through towns in epidemics every few years. Though most people recovered quickly from polio, some suffered temporary or permanent paralysis and even death. Many polio survivors were disabled for life. They were a visible, painful reminder to society of the enormous toll this disease took on young lives.

Polio is the common name for poliomyelitis, which comes from the Greek words for grey and marrow, referring to the spinal cord, and the suffix –itis, meaning inflammation. Poliomyelitis, shortened, became polio. For a time, polio was called infantile paralysis, though it did not affect only the young.

Symptoms and Causative Agent

Polio is caused by one of three types of poliovirus, which are members of the Enterovirus genus.

In about 95% of all polio cases, the person has no symptoms at all. These are known as asymptomatic cases. The rest of polio cases can be divided into three types: abortive polio, non-paralytic polio, and paralytic polio.

Abortive polio: In these cases, polio is a mild illness, with viral-like symptoms such as fever, fatigue, headache, sore throat, nausea, and diarrhea.

Non-paralytic polio: These cases typically involve the symptoms of abortive polio, with additional neurological symptorms, such as sensitivity to light and neck stiffness.

Paralytic polio: The first signs of paralytic polio, after an initial period of viral-like symptoms, typically begin with loss of superficial reflexes and muscle pain or spasms. Paralysis, usually asymmetric, follows. Fewer than 1%-2% of people who contract polio become paralyzed. In most cases of paralytic polio, the patient recovers completely. However, for a certain number of people, paralysis or muscle weakness remains for life.

Transmission

Polio is a highly infectious illness that spreads through contact between people, by nasal and oral secretions, and by contact with contaminated feces. Poliovirus enters the body through the mouth, multiplying along the way to the digestive tract, where it further multiplies.  

Treatment and Care

Polio has no cure, so prevention is the most effective means to combat it. Certain drugs and therapies can offer supportive care for patients to counter some of the effects of muscle involvement. Patients who progress to paralysis of muscles involved in breathing receive artificial breathing support, which may be discontinued if the patient regains use of the affected muscles.

Complications

In severe cases of paralytic polio, the throat and chest may be paralyzed. Death may result if the patient does not receive artificial breathing support. Between 2%-5% of children affected with paralytic polio die, whereas for adults, 15%-30% die.

Available Vaccines and Vaccination Campaigns

Because of widespread vaccination, polio was eliminated from the Western Hemisphere in 1994. Today, it continues to circulate in a handful of countries, with occasional spread to neighboring countries. (Endemic countries are Afghanistan, Nigeria, and Pakistan as of 2013.) Vigorous vaccination programs are being conducted to eliminate these last pockets. Polio vaccination is still recommended worldwide because of the risk of imported cases.

U.S. Vaccination Recommendations

In the United States, children are recommended to receive the inactivated polio vaccine at 2 months and 4 months of age, and then twice more before entering elementary school.


Source

Centers for Disease Control and Prevention. Epidemiology and Prevention of Vaccine-Preventable Diseases. Poliomyelitis. (512 KB). Atkinson W, Wolfe S, Hamborsky J, McIntyre L, eds. 11th ed. Washington DC: Public Health Foundation, 2009. Accessed 7/31/2014.

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Last update 31 July 2014

Timeline Entry: 6/17/1916 New York City Polio Epidemic

Graph showing polio cases in the 1916 New York City epidemic
 
Notice of consequences of disregarding measures in place to prevent polio transmission
 
The Historical Medical Library of The College of Physicians of Philadelphia
Table summarizing reported polio cases in the Philadelphia 1916 epidemic
 
The Historical Medical Library of The College of Physicians of Philadelphia
Shaded areas show places particularly hard hit in the 1916 polio epidemic.
 
The Historical Medical Library of The College of Physicians of Philadelphia
Map of distribution of reported polio cases, 1910, Washington, DC
 
The Historical Medical Library of The College of Physicians of Philadelphia
Polio patients performing therapeutic exercises, New York, circa 1914
 
The Historical Medical Library of The College of Physicians of Philadelphia
Polio cases and deaths in New York City 1916
 
The Historical Medical Library of The College of Physicians of Philadelphia
Massage therapy for a young polio sufferer in the 1916 U.S. polio epidemic
 
The Historical Medical Library of The College of Physicians of Philadelphia
These polio patients all suffered eye paralysis.
 
The Historical Medical Library of The College of Physicians of Philadelphia
A public health hospital in New York City receives a polio patient in 1916.

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The College of Physicians of Philadelphia
C. Everett Koop, MD, former U.S. Surgeon General, discusses polio epidemics.
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Health officials announced a polio epidemic centered in Brooklyn, New York. As was typical with polio outbreaks, infections surfaced in the summer months.

More than 2000 people would die in New York City alone. Across the United States in 1916, polio took the lives of about 6,000 people, leaving thousands more paralyzed.

Summer epidemics would come to be common in this era and would lead to widespread closures of pools, amusements parks, and other places where children gathered.

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