The History of Vaccines Blog

Cholera Outbreak in Haiti Continues

This cholera patient is drinking oral rehydration solution in order to counteract his cholera-induced dehydration. Photo: CDC/19 Cholera affects 3-5 million people each year, killing more than 100,000. The diarrheal disease, spread by contaminated food and water, is often a major problem in disaster areas where a clean water supply and sanitation facilities are limited or unavailable.

Haiti, still recovering from the 7.0-magnitude earthquake that devastated Port-au-Prince on January 12, 2010, is experiencing a growing cholera outbreak that has so far killed 259 people. Haiti’s Le Ministère de la Santé Publique et de la Population (Ministry for Public Health and the Population, or MSPP) reported 3,342 confirmed cases as of October 26, but Dr. Jon Andrus, Deputy Director of the Pan American Health Organization (PAHO) stated in a press briefing on October 25 that the true number of cases is likely to be significantly higher than the confirmed number. Dr. Andrus noted that about 75% of people infected with cholera do not experience symptoms (called “asymptomatic infection”). These individuals can still spread the bacteria, however. Dr. Andrus also stated that while the increase in new cases has recently slowed, there is still a concern that the Haitian outbreak could spread to the Dominican Republic. More

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Rarely Seen: Dr. Austrian's Bacterial Incubator

Austian's Bacterial Incubator, The College of Physicians of Philadelphia Anna Dhody, Mütter Museum Curator, today describes another item in the museum's recently unveiled Rarely Seen exhibit. A vital tool in biomedical research, this bacterial incubator was used to grow and sustain cell and microbiological cultures. The incubator mimicked the optimal environmental conditions for a particular organism when the researcher adjusts the humidity, temperature, and atmospheric conditions. Manufactured by the ELCONAP, Electric Heat Control Apparatus Co. of Newark, New Jersey, this incubator was used by Robert Austrian, MD (1916-2007), a pioneering physician, epidemiologist, and microbiologist in researching infectious diseases. Dr. Austrian was also a Fellow of The College of Physicians of Philadelphia from 1963 to 2007 and served as its President from 1988 to 1990. More

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Rarely Seen: Our Curator Discusses the Iron Lung

The iron lung became one of the most iconic objects of the polio scourge. Mütter Museum Curator Anna Dhody describes the iron lung featured in the museum's new exhibit, Rarely Seen. This exhibit offers visitors a glimpse of objects that have  not been displayed for decades or are recent acquisitions that have never been exhibited. Some of the instruments represent the pinnacle of medical knowledge for their time, while others had mixed and sometimes detrimental medical results.

Many people remember when the threat of polio was omnipresent. Public pools and movie theaters were closed and parents lived in fear that their children could be struck down at any moment, unable to move or breathe. No one was safe: while the poliomyelitis virus affected mainly children, adults were also susceptible. The iron lung became one of the most iconic objects of the polio scourge, a symbol of the epidemics of the 1940s and 50s. More

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Which vaccine has had the greatest impact?

Lantern Slide, The College of Physicians of Philadelphia We hosted a contest for fans of the Mütter Museum/The College of Physicians of Philadelphia on Facebook.They had a chance to win prizes (a stuffed pathogen, a cool keychain, and a calendar) from the Mütter Museum store. The contest is now over!

The rules: Submit a comment to this blog post that describes which vaccine you think has had the greatest impact on human health and explains. The comment must comply with our blog comment/moderation policy.

We chose THREE winners from those of you who posted a comment. More

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Measles Vaccine, 1960

Measles Pamplets The New York Times on October 5 ran a short piece on first mentions of measles and measles preventives on its pages. The item focuses on John Enders’s early measles vaccine, tested in 1960 at the Willowbrook State School in New York and in Nigeria.

Read on for History of Vaccines videos on early measles vaccines. More

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Polio: Past, Present and Future

Member of an Emergency Citizens Group in Oklahoma City during a 1963 Polio Eradication Campaign, CDC A global effort to eradicate polio began in 1988. At the time, the disease was endemic in more than 125 countries; by 2006, only Afghanistan, India, Nigeria and Pakistan still saw endemic polio transmission. Still, despite this progress, the disease has stubbornly refused to disappear completely.

The Center for Vaccine Ethics and Policy blog took note this week of a Lancet Infectious Diseases article titled "Reflection and Reaction: Reconstructing the past of poliovirus eradication efforts". The blog post suggested that a review of the eradication initiative’s historical record, and a more cautious outlook toward its potential outcomes, might be wise.

This post was unfortunately coincidental with news of expanding polio outbreaks in Africa. The World Health Organization (WHO) announced on Friday, October 1 that a continuing outbreak of polio in Angola must be stopped to prevent “international consequences.” The disease is spreading not only within Angola but also into the Democratic Republic of Congo. It is the only expanding African outbreak of the disease, and puts the continued progress of the eradication program at risk. More

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Welcome to History of Vaccines!

If you've been following our blog over the past few months, you'll notice that our look has changed. Our website, historyofvaccines.org, is now in previews after several years of planning and about a year of development.

The site provides a historical and scientific context for the development of immunizations. It features not only holdings of the Historical Medical Library and Mütter Museum of The College of Physicians of Philadelphia, but also images, text, and video from a variety of public and private sources.

We invite you to explore the site -- the media-rich timelines on yellow fever, polio, smallpox, measles, diphtheria, and other diseases; the educational activities on how vaccines work, how vaccines are made, and how the scientific method is employed; the variety of articles on social and medical issues surrounding vaccination; and the gallery, which houses over 400 images and videos.

The History of Vaccines will officially launch on November 3, 2010, with an event here in Philadelphia: Stanley A. Plotkin, MD, developer of the rubella vaccine in current worldwide use, and emeritus professor of The Wistar Institute and The University of Pennsylvania, will give the Samuel X Radbill lecture entitled "Four Centuries of Vaccinology." Register HERE for the free event.

If you'd like to be notified about future History of Vaccines events and content releases, join our email list. More

Rarely Seen: Iron Lung

Collection of the Mütter Museum of The College of Physicians of Philadelphia Here at The College of Physicians of Philadelphia, our own Mütter Museum is preparing an exhibit entitled Rarely Seen: Hidden Collections of the Mütter Museum. Visitors will have the chance to see some rarely or never before seen items. Too large to display in the permanent museum galleries, these fascinating objects will briefly have a home in our temporary exhibit space.  Of particular interest to the History of Vaccines project is an iron lung manufactured by J.H. Emerson Co. as well as  a bacterial incubator used by Robert Austrian, MD, a pioneer researcher in pneumococcal disease and developer of the polysaccharide pneumococcal vaccine. This exhibit will be on display from October 2010 through January 2011.

Over the next few days we’ll post more pictures of the iron lung along with the tale of how it came to the Mütter Museum. More

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Library Treasures: Dover on Sydenham’s Smallpox Treatment

Dover's Title Page, The College of Physicians of Philadelphia In anticipation of the launch of the full History of Vaccines website on September 29, we offer here an excerpt from our collection of smallpox information.

Dover's Title Page Dover's Title Page, The College of Physicians of Philadelphia Thomas Sydenham (1624-1689), a noted English doctor, had observed that the rich seemed to have a higher mortality rate from smallpox than the poor. This led him to conclude that contemporary medical treatments, largely inaccessible to the poor, might be more harmful than helpful in mild smallpox cases. And yet, the care he provided his own patients was quite elaborate. Thomas Dover, a patient of Sydenham and a future doctor, documented his treatment at Sydenham’s hands for a serious case of smallpox. Below is Dover’s description; it is likely that the year is 1684. More

Robert Chanock, Renowned Virologist, Dies at 86

Photomicrographic detection of respiratory syncytial virus (RSV) using indirect immunofluorescence technique. CDC/ Dr. H. Craig Before Robert Chanock, MD, joined the National Institute of Allergy and Infectious Diseases (NIAID) in 1957, researchers had not identified a culprit for a constellation of serious respiratory illnesses that affected infants and children each year, particularly in the winter. Soon after Chanock joined NIAID’s Laboratory of Infectious diseases, however, he and his colleagues identified and named the virus: respiratory syncytial virus. RSV, as it is commonly known, is the most common cause of bronchiolitis and pneumonia among American children less than one year of age.

When asked if he had any advice for parents worried about RSV, Chanock alluded to the virus’s tendency to spread during the winter and famously quipped (though he noted that there was some truth to the remark) that parents should have their babies in the spring. Through his research efforts, however, he and his colleagues provided a better form of protection against the virus: an antibody to protect against RSV in infants at high risk for RSV illnesses.

Throughout his career, a great deal of Chanock’s research was in the field of respiratory disease. He collaborated with other researchers to discover parainfluenza viruses that cause childhood respiratory illnesses, isolate strains of the virus that causes the common cold, and isolate one of the causes of bacterial pneumonia. More