Forty-six years after the successful Salk poliovirus vaccine trials of 1954, concerns about cases of polio developing from use of the OPV led to the United States adopting an IPV-only vaccine schedule. Sabin’s vaccine was still used in other parts of the world where polio still circulated.
Merits of OPV and IPV
- Merits of OPV and IPV
Stanley Plotkin, who worked on an early oral poliovirus vaccine, discusses the advantages and disadvantages of the live attenuated vaccine (Sabin type) and the killed virus vaccine (Salk type, or IPV). The IPV is used in the United States today.
- Footage courtesy of The Vaccine Makers project
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