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The rabies vaccine produced at the Wistar Institute, called HDCV (human diploid cell vaccine), was licensed in Europe in 1976 and in the United States in 1980. One of its principal advantages was that the vaccine was given in five injections rather than the course of 14-21 injections used in the older vaccines.

HDCV is still widely used, but it is expensive to produce. Other rabies vaccines containing viruses grown in other types of cell culture (chick embryo, a cell line derived from African green monkey kidney, fetal rhesus cells, and hamster kidney cells) have been licensed in different parts of the world. A few vaccines created with nervous system tissue continue to be used in Asia, Africa, and South America.

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Diseases & Vaccines