Robbins 5: Polysaccharide v. Conjugate Vaccine
- Description:
- John B. Robbins, MD, discusses the reason the first Haemophilus influenzae type b vaccine did not induce an immune response in infants: in the very young, the polysaccharide used as the antigen is too simple to stimulate antibody production. The polysaccharide does induces antibody production in adults, but they are not so vulnerable to the disease. Robbins, an NIH researcher, introduced the concept of conjugate synthesis for polysaccharide and peptide vaccines, and developed the following vaccines: Haemophilus influenzae type b conjugate, Streptococcus pneumoniae capsular polysaccharide conjugate, Salmonella typhi Vi conjugate, and monocomponent Bordetella pertussis toxoid.
- Copyright:
- The College of Physicians of Philadelphia
- Date Created/Taken:
- October 13, 2011
- Related Timeline Links:
- Conjugate Hib Vaccine Licensed
