The Historical Medical Library at The College of Physicians is full of fascinating items, and we’ve run across many of them while developing the History of Vaccines website. One such item is a pamphlet written by Benjamin Franklin and an English doctor, outlining American and English experiences with inoculation against smallpox. This process, also called variolation, involved transferring some matter from a smallpox sore on a person with a mild case of the disease into a cut or scratch on the body of a healthy person. The usually mild local reaction would most often protect the inoculated person from contracting smallpox.
As you may have learned from our smallpox timeline, Franklin lost his four-year-old son to smallpox in 1736. He became an advocate of inoculation, arguing that although it was not without risk, it was far safer than natural infection. In 1759, Franklin asked a friend, London physician William Heberden, to write a pamphlet outlining the process of inoculation, so that anyone could learn how to perform the operation. Franklin then wrote an introduction for the pamphlet, stating that Heberden paid for printing “a very large impression” of the pamphlet to be distributed for free in America. A copy of the pamphlet “Some Account Of the Success of Inoculation for the Small-Pox in England and America together with Plain Instructions, By which any Person may be enabled to perform the Operation, and conduct the Patient through the Distemper,” is in the Historical Medical Library. More